HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo
Table 4
The frequency of celiac disease-predisposing HLA-DQ haplotypes and genotypes detected among Albanian pediatric celiac disease patients from Kosovo () and the control group ().
Patients ()
Control group ()
HLA-DQ haplotypes
(%)
(%)
Susceptible haplotypes
DQ2.5cis
48 (40.01)
19 (7.66)
<0.0001
DQ2.5trans
8 (6.66)
3 (1.20)
0.0088
DQ8
5 (4.17)
20 (8.06)
0.1712
Fractional susceptible haplotypes
DQ2.2
14 (11.66)
14 (6.45)
0.0631
DQ2.3
0
1 (0.41)
0.8170
DQ7
17 (14.16)
67 (27.01)
0.0068
Nonsusceptible haplotypes
DQ4
1 (0.83)
6 (2.41)
0.3191
DQ5
15 (12.50)
68 (27.41)
0.0017
DQ6
12 (10.00)
48 (19.35)
0.0252
DQ9
0
2 (0.80)
0.5650
HLA-DQ genotypes
DQ2 and/or DQ8 positive
57 (95.00)
50 (40.32)
<0.0001
Dual-dosage susceptible genotypes
DQ2.5/DQ2.2
12 (20.00)
2 (1.61)
0.0005
DQ2.5/DQ2.5
3 (5.00)
0
0.0738
DQ2.2/DQ2.2
0
2 (1.61)
0.5616
DQ8/DQ2.5
3 (5.00)
1 (0.81)
0.1091
DQ8/DQ2.2
0
0
n/a
DQ8/DQ8
0
1 (0.81)
0.8144
Sole-dosage susceptible genotypes
DQ2.5/DQX
35 (58.33)
19 (15.32)
<0.0001
DQ2.2/DQX
2 (3.33)
8 (6.45)
0.3902
DQ8/DQX
2 (3.33)
17 (13.71)
0.0459
DQ2 and/or DQ8 negative
3 (5.00)
74 (59.68)
<0.0001
Legend (alphabetic order): DQ2.5 = HLA-DQA105~DQB102 (HLA-DRB103); DQ8 = HLA-DQA103~DQB103:02 (HLA-DRB104); DQ2.2 = HLA-DQA102~DQB102 (HLA-DRB107); DQ2.3 = HLA-DQA103~DQB102 (HLA-DRB104/09/11); DQ7 = HLA-DQB103:01 (HLA-DRB111/12/X); DQ4, DQ5, DQ6, and DQ9 were assigned if HLA-DQB104, HLA-DQB105, HLA-DQB106, and HLA-DQB103:03 alleles were present; DQX = presence of any other HLA-DQB1 allele than HLA-DQ2 and/or HLA-DQ8; = number of tested individuals; = number of HLA-DQ haplotype/genotype occurrence; n/a = not applicable (due to ).
