Laparoscopic versus Open Surgery in Lateral Lymph Node Dissection for Advanced Rectal Cancer: A Meta-Analysis

Table 2

Sensitivity analysis comparison of laparoscopic/robotic-assisted laparoscopic LLND and open LLND.

Outcomes of interest	Studies ()	L/RL ()	O ()	WMD/OR/HR (95% CI)	value	Study heterogeneity
							df	(%)	value
Operative time (min)	5	288	280	96.98† (12.52-181.44)	0.02	98.49	4	96	<0.00001
Estimated blood loss (ml)	5	288	280	-615.35† (-694.06 to -536.64)	<0.00001	3.37	4	0	0.50
Postoperative hospital stay (days)	3	143	145	-3.40† (-5.27 to -1.53)	0.0004	1.70	2	0	0.43
Postoperative complications	4	203	192	0.37 (0.15-0.91)	0.03	8.78	3	66	0.03
Lateral lymph node harvest ()	5	339	341	0.01 (-4.53 to 4.55)	1.00	31.57	4	87	<0.00001
Lateral lymph node metastasis	3	249	250	1.09 (0.69-1.74)	0.70	1.76	2	0	0.42
R0 resection status	6	353	330	2.17 (1.14-4.15)	0.02	6.91	5	28	0.23
Local recurrence	4	203	192	0.55 (0.30-1.01)	0.05	1.12	3	0	0.77
3-year overall survival	4	269	257	1.22 (0.44-3.38)	0.71	1.24	3	0	0.74
3-year disease-free survival	4	269	257	0.98 (0.67-1.44)	0.90	1.09	3	0	0.78

L = laparoscopic surgery; RL = robotic-assisted laparoscopic surgery; O = open surgery; WMD = weighted mean difference; OR = odds ratio; HR = hazard ratio; CI = confidence interval; df = degrees of freedom. HR; †WMD.