Review Article

Advances in Translational Research and Clinical Care in Pancreatic Cancer: Where Are We Headed?

Table 2

Selected active combination immunotherapy trials.

Pancreatic cancer classificationClinical trial no.

Vaccine+IO
 GVAX+nivolumabSurgically resectableNCT02451982
Vaccine+IO+radiation
 GVAX+pembrolizumab+SBRTLocally advancedNCT02648282
 GVAX+nivolumab+SBRTBorderline resectableNCT03161379
IO+chemotherapy
 Atezolizumab+chemotherapyMetastaticNCT03193190
IO+radiation
 Nivolumab+radiationMSS pancreatic cancerNCT03104439
IO+chemoradiation
 Pembrolizumab+chemoradiationBorderline resectableNCT02305186
 Nivolumab+chemo+SBRTLocally advancedNCT03563248

IO: immunotherapy; SBRT: stereotactic body radiation therapy; MSS: microsatellite stable.