Diagnostic and Clinical Significance of Serum Levels of D-Lactate and Diamine Oxidase in Patients with Crohn’s Disease

Table 3

Accuracy and ROC analyses of D-LA, DAO, ESR, and CRP in differentiating CD active and CD remission.

Diagnostic index	AUC (95% CI)	Standard error	value	Youden (max)	Cut value	Sensitivity	Specificity
D-LA	81.5 (0.692, 0.904)	0.06	<0.001	0.623	14.91 mg/L	68.97	93.33
DAO	74.8 (0.618, 0.852)^△	0.07	<0.001	0.525	9.75 U/L	75.86	76.67
ESR	70.5 (0.572, 0.816)	0.07	<0.05	0.386	15 mm/h	58.62	80.00
CRP	78.4 (0.658, 0.881)	0.06	<0.001	0.487	7.85 mg/L	62.07	86.67
Comb	86.1 (0.746, 0.937)^#	0.05	<0.001	0.659	0.47	75.86	90.00

CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; D-LA: D-lactate; DAO: diamine oxidase; AUC: area under the curve; Comb: combined predictors. Compared with ESR and CRP, ^#; compared with ESR and CRP, ; compared with ESR and CRP, ^△.