The Pre- and Postoperative FIB-4 Indexes Are Good Predictors to the Outcomes of HBV-Related HCC Patients after Resection

Table 2

Univariate and multivariate analysis of prognostic factors for RFS in CHB-HCC patients after curative hepatectomy.

Variable	Comparison	Univariate		Multivariate
		HR (95% CI)	value	HR (95% CI)	value
Age (years)	>60 vs. ≦60	1.345 (1.042–1.736)	0.023
Sex	Male vs. female	0.970 (0.689–1.364)	0.860
DM	Yes vs. no	2.036 (1.493–2.778)	<0.001	1.887 (1.702–2.716)	0.001
AFP (ng/mL)	>20 vs. ≦20	1.214 (0.945–1.559)	0.130
Platelet (10^9/L)	≦150 vs. >150	1.408 (1.091–1.816)	0.009
Albumin (g/dL)	≦3 vs. >3	1.617 (1.076–2.429)	0.021
Liver cirrhosis	Yes vs. no	2.073 (1.612–2.668)	<0.001	2.117 (1.513–2.960)	<0.001
MELD score	>14 vs. ≦14	0.967 (0.430–2.174)	0.935
Child-Pugh grade	B vs. A	1.400 (0.764–2.563)	0.276
FIB-	>2 vs. ≦2	1.902 (1.491–2.460)	<0.001	1.085 (1.102–1.163)	0.022
Tumor size (cm)	>5 vs. ≦5	1.370 (1.017–1.849)	0.039	1.615 (1.097–2.379)	0.015
Tumor no.	Multiple vs. single	1.395 (0.840–2.316)	0.198
TNM stages	III vs. I + II	1.599 (1.072–2.385)	0.021
Histology stages	III vs. I+II	1.893 (1.005–3.565)	0.048	3.306 (1.441–7.581)	0.005
Vascular invasion	Yes vs. no	1.536 (1.197–1.970)	0.001	1.537 (1.132–2.088)	0.006

DM = diabetes mellitus; MELD = model for end-stage liver disease; FIB-4 = fibrosis-4.