The Pre- and Postoperative FIB-4 Indexes Are Good Predictors to the Outcomes of HBV-Related HCC Patients after Resection

Table 4

Univariate and multivariate analysis of prognostics factors for OS in CHB-HCC patients after curative hepatectomy.

Variable	Comparison	Univariate		Multivariate
		HR (95% CI)	value	HR (95% CI)	value
Age (years)	>60 vs. ≦60	1.411 (0.949–2.167)	0.116
Sex	Male vs. female	1.096 (0.596–2.017)	0.767
DM	Yes vs. no	3.021 (1.889–4.832)	<0.001	2.898 (1.628–5.160)	<0.001
AFP (ng/mL)	>20 vs. ≦20	1.609 (1.037–2.498)	0.034	2.020 (1.164–3.507)	0.012
Platelet (10^9/L)	≦150 vs. >150	1.539 (1.002–2.363)	0.049
Albumin (g/dL)	≦3 vs. >3	1.920 (1.018–3.622)	0.044
Liver cirrhosis	Yes vs. no	1.937 (1.259–2.980)	0.003
MELD score	>14 vs. ≦14	1.443 (0.455–4.574)	0.534
Child-Pugh grade	B vs. A	2.328 (1.017–5.374)	0.045
FIB-	>2 vs. ≦2	2.207 (1.420–3.429)	<0.001	2.940 (1.622–5.329)	<0.001
Tumor size (cm)	>5 vs. ≦5	1.385 (0.846–2.268)	0.195
Tumor no.	Multiple vs. single	0.926 (0.358–2665)	0.963
TNM stages	III vs. I+II	3.069 (1.804–5.223)	<0.001
Histology stages	III vs. I+II	6.069 (3.129–11.779)	<0.001	6.400 (2.501–16.377)	<0.001
Vascular invasion	Yes vs. no	1.906 (1.248–2.911)	0.003

DM = diabetes mellitus; MELD = model for end-stage liver disease; FIB-4 = fibrosis-4.