Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms
Table 1
Clinical characteristics based on the classification of digestive symptoms with or without diarrhea of Digestive Only and Digestive+Respiratory patients on admission.
Items
Total (including Respiratory Only)
Digestive Only
Digestive+Respiratory
With diarrhea ()
Without diarrhea ()
With diarrhea ()
Without diarrhea ()
With diarrhea ()
Without diarrhea ()
Age (years)
51.6 (27-84)
62.0 (27-92)
0.128
55.5 (32-84)
67.6 (32-92)
0.424
49.5 (27-81)
61.4 (36-84)
0.001
Gender (male/female)
23/44
68/71
0.048
6/17
7/18
0.882
17/27
13/12
0.282
Fever
48 (71.6%)
90 (64.7%)
0.324
13 (56.5%)
6 (24.0%)
0.021
35 (79.5%)
19 (76.0%)
0.731
Highest temperature, °C
39.8
39.8
-
39
39.8
-
39.8
39.5
-
Organ function injury
TBil (≤19.0 μmol/L)
7 (10.4%)
10 (7.2%)
0.436
2 (8.7%)
2 (8.0%)
1
5 (11.4%)
2 (8.0%)
1
DBil (≤6.8 μmol/L)
6 (9.1%)
15 (10.9%)
0.696
3 (13.0%)
0 (0.0%)
0.205
3 (7.0%)
2 (8.0%)
1
ALT (≤35 U/L)
17 (25.4%)
54 (39.1%)
0.052
7 (30.4%)
8 (32.0%)
0.907
10 (22.7%)
9 (36.0%)
0.235
AST (≤40 U/L)
6 (9.0%)
25 (18.1%)
0.086
2 (8.7%)
5 (20.0%)
0.484
4 (9.1%)
6 (24.0%)
0.182
ALP (<150 U/L)
0 (0.0%)
5 (3.6%)
0.274
0 (0.0%)
2 (8.0%)
0.508
0 (0.0%)
0 (0.0%)
-
GGT (<50 U/L)
16 (23.9%)
29 (21.0%)
0.642
4 (17.4%)
6 (24.0%)
0.836
12 (27.3%)
3 (12.0%)
0.139
LDH (<245 U/L)
23 (34.3%)
46 (34.1%)
0.971
9 (39.1%)
10 (40.0%)
0.951
14 (31.8%)
8 (32.0%)
0.988
hsTNI (<26.2 ng/L)
0 (0.0%)
4 (3.5%)
0.463
0 (0.0%)
1 (4.8%)
1
0 (0.0%)
0 (0.0%)
-
D-dimer (<0.5 ng/L)
25 (45.5%)
57 (52.3%)
0.408
7 (36.8%)
12 (75.0%)
0.041
18 (50.0%)
11 (50.0%)
1
Immune inflammation
WBC (3.5-9.5 G/L)
7 (10.4%)
29 (21.2%)
0.059
2 (8.7%)
4 (16.7%)
0.666
5 (11.4%)
6 (24.0%)
0.3
Neutrophil (1.8-6.3 G/L)
7 (10.4%)
28 (20.4%)
0.075
3 (13.0%)
5 (20.8%)
0.701
4 (9.1%)
6 (24.0%)
0.182
Lymphocyte (1.1-3.2 G/L)
18 (26.9%)
52 (38.0%)
0.117
6 (26.1%)
10 (41.7%)
0.260
12 (27.3%)
7 (28.0%)
0.948
CRP (<8 mg/L)
21 (38.9%)
66 (54.5%)
0.056
7 (36.8%)
9 (37.5%)
0.965
14 (40.0%)
9 (45.0%)
0.718
ESR (<15 mm/h)
40 (71.4%)
103 (84.4%)
0.043
14 (77.8%)
20 (90.9%)
0.381
26 (68.4%)
19 (86.4%)
0.122
IL-2 (0.1-4.1 pg/ml)
3 (4.8%)
1 (0.8%)
0.214
3 (13.0%)
1 (4.2%)
0.348
0 (0.0%)
0 (0.0%)
-
IL-4 (0.1-3.2 pg/ml)
4 (6.3%)
11 (8.8%)
0.558
2 (8.7%)
5 (20.8%)
0.416
2 (5.0%)
1 (5.0%)
1
IL-6 (0.1-2.9 pg/ml)
59 (93.7%)
119 (95.2%)
0.918
20 (87.0%)
23 (95.8%)
0.348
39 (97.5%)
18 (90.0%)
0.255
IL-10 (0.1-5.0 pg/ml)
6 (9.5%)
20 (16.0%)
0.225
3 (13.0%)
8 (33.3%)
0.101
3 (7.5%)
2 (10.0%)
1
TNF-a (0.1-23 pg/ml)
0 (0.0%)
6 (4.8%)
0.184
0 (0.0%)
0 (0.0%)
-
0 (0.0%)
0 (0.0%)
-
IgG (7.51-15.6 g/L)
3 (13.0%)
3 (6.0%)
0.576
2 (15.4%)
1 (6.7%)
0.583
1 (10.0%)
1 (25.0%)
0.505
IgM (0.46-3.04 g/L)
1 (4.3%)
4 (8.0%)
0.940
0 (0.0%)
0 (0.0%)
-
1 (10.0%)
0 (0.0%)
1
C3 (0.79-1.52 g/L)
3 (13.0%)
14 (28.0%)
0.160
2 (15.4%)
4 (26.7%)
0.655
1 (10.0%)
1 (25.0%)
0.505
C4 (0.16-0.38 g/L)
3 (13.0%)
13 (26.0%)
0.214
0 (0.0%)
4 (26.7%)
0.102
3 (30.0%)
2 (50.0%)
0.580
CD3+T lymphocytes
19 (30.6%)
30 (22.4%)
0.214
7 (31.8%)
8 (33.3%)
0.913
12 (30.0%)
7 (29.2%)
0.944
CD4+T lymphocytes
21 (33.9%)
43(32.1%)
0.805
8 (36.4%)
9 (37.5%)
0.936
13 (32.5%)
7 (29.2%)
0.781
CD8+T lymphocytes
12 (19.4%)
26 (19.4%)
0.994
3 (13.6%)
5 (20.8%)
0.702
9 (22.5%)
6 (25.0%)
0.819
Indicators of organ function injury and immune inflammation were expressed in terms of the number and percentage of abnormalities; Digestive Only: gastrointestinal symptoms cases; Respiratory Only: respiratory symptoms cases; Digestive+Respiratory: both digestive and respiratory symptoms. Because not all patients have the same test, the denominators of each indicator may be inconsistent in their calculations. A statistical test proved that the deletions belong to random deletions and have no influence on the results (Supplementary Table 1). A significance level of was used.
