RNF43 Mutations in IPMN Cases: A Potential Prognostic Factor

Table 5

Correlation between clinicopathological features and KRAS/GNAS/RNF43 mutation status in IPMN patients.

Clinicopathological features	KRAS				GNAS				RNF43
	Wild type	Mutated	Mutated/total (%)	value	Wild type	Mutated	Mutated/total (%)	value	Wild type	Mutated	Mutated/total (%)	value
No. of patients	26	35	35/61 (57)		21	40	40/61 (66)		56	5	5/61 (8)
Age (mean, years)	62.3	63.6		0.625^☆	59.1	65.1		0.042^☆¶	63.1	62.8		0.952^☆
Sex
Male	17	22	22/39 (56)	0.839^†	12	27	27/39 (69)	0.423^†	35	4	4/39 (10)	0.645^△
Female	9	13	13/22 (59)		9	13	13/22 (59)		21	1	1/22 (5)
Pancreatitis
Yes	8	13	13/21 (62)	0.604^†	7	14	14/21 (67)	0.896^†	21	0	0/21 (0)	0.154^△
No	18	22	22/40 (55)		14	26	26/40 (65)		35	5	5/40 (13)
Size (cm)
≤3	12	12	12/24 (50)	0.376^†	8	16	16/24 (67)	0.661^†	22	2	2/24 (8)	1.000^△
>3-≤5	8	17	17/25 (68)		10	15	15/25 (60)		23	2	2/23 (9)
>5	6	6	6/12 (50)		3	9	9/12 (75)		11	1	1/12 (8)
Location
Head	19	25	25/44 (57)	0.692^△	16	28	28/44 (64)	0.907^△	40	4	4/44 (9)	0.263^△
Body and tail	4	8	8/12 (67)		4	8	8/12 (67)		12	0	0/12 (0)
Both	3	2	2/5 (40)		1	4	4/5 (80)		4	1	1/5 (20)
Imaging classification
Main duct	17	19	19/36 (53)	0.605^†	15	21	21/36 (58)	0.316^†	34	2	2/36 (6)	0.335^△
Branch duct	6	9	9/15 (60)		3	12	12/15 (80)		14	1	1/15 (7)
Both	3	7	7/10 (70)		3	7	7/10 (70)		8	2	2/10 (20)
Subtype
Gastric	4	7	7/11 (64)	0.261^△	5	6	6/11 (55)	<0.001^△¶	11	0	0/11 (0)	0.728^△
Intestinal	10	19	19/29 (66)		2	27	27/29 (93)		25	4	4/29 (14)
Pancreatobiliary	8	8	8/16 (50)		9	7	7/16 (44)		15	1	1/16 (6)
Oncocytic	4	1	1/5 (20)		5	0	0/5 (0)		5	0	0/5 (0)
Dysplasia
Low	11	13	13/24 (54)	0.532^†	7	17	17/24 (71)	0.819^†	24	0	0/24 (0)	0.092^△
High	5	4	4/9 (44)		3	6	6/9 (67)		7	2	2/9 (22)
Infiltration
Yes	10	18	18/28 (64)	0.315^†	11	17	17/28 (61)	0.703^†	25	3	3/28 (11)	0.421^△
No	16	17	17/33 (52)		10	23	23/33 (63)		31	2	2/33 (6)
Differentiation of invasive carcinoma
High	7	9	9/16 (56)	0.339^△	3	13	13/16 (81)	0.054^△	13	3	3/16 (19)	0.464^△
Intermediate	1	7	7/8 (87.5)		5	3	3/8 (38)		8	0	0/8 (0)
Low	2	2	2/4 (50)		3	1	1/4 (25)		4	0	0/4 (0)
Extent of invasive carcinoma
Intrapancreatic	4	8	8/12 (67)	0.589^†	3	9	9/12 (75)	0.295^†	11	1	1/12 (8)	0.824^△
Extrapancreatic	6	10	10/16 (63)		8	8	8/16 (50)		14	2	2/16 (13)
Nerve invasion
Yes	0	6	6/6 (100)	0.082^△	5	1	1/6 (17)	0.029^△¶	6	0	0/6 (0)	0.637^△
No	10	12	12/22 (55)		6	16	16/22 (73)		19	3	3/22 (14)
Lymph node metastasis
Yes	2	3	3/5 (60)	1.000^△	3	2	2/5 (40)	0.505^△	5	0	0/5 (0)	0.770^△
No	8	16	16/24 (67)		8	16	16/24 (67)		21	3	3/24 (13)
Correlation between status of KRAS and GNAS												0.979^†
Correlation between status of KRAS and RNF43												0.641^△
Correlation between status of GNAS and RNF43												0.111^△

^☆-test. ^†Chi-square test. ^△Fisher’s exact test. ^¶Statistically significant ().