Risk Factors of Lymph Node Metastasis in Patients with Pancreatic Neuroendocrine Tumors (PNETs)

Table 2

Results of univariate and multivariable analysis for the possible factors of lymph node metastasis.

	Univariate		Multivariable
	OR; (95% CI)	value	Adjusted OR; (95% CI)	value
Age^a	0.99 (0.98-1.01)	0.163
Sex		0.867
Male	Reference
Female	1.02 (0.83-1.25)
Race		0.034		0.058
White	Reference		Reference
Black	1.24 (0.91-1.70)		1.28 (0.92-1.78)	0.144
Hispanic	0.80 (0.59-1.10)		0.75 (0.55-1.04)	0.081
Asian	0.64 (0.44-0.94)		0.63 (0.42-0.92)	0.018
Other	0.67 (0.28-1.62)		0.80 (0.32-2.00)	0.629
Marital status		0.420
Unmarried	Reference
Married	1.06 (0.85-1.33)
Unknown	0.78 (0.48-1.28)
Insurance status		0.165
Uninsured	Reference
Insured	1.33 (0.68-2.57)
Unknown	1.74 (0.85-3.58)
Tumor location		<0.001		<0.001
Head	Reference		Reference
Body and tail	0.54 (0.43-0.67)		0.54 (0.43-0.68)	<0.001
Overlapping	0.69 (0.43-1.08)		0.70 (0.44-1.13)	0.144
Other	0.68 (0.48-0.97)		0.69 (0.48-0.99)	0.045
Tumor size^a	1.01 (1.00-1.05)	0.008	1.03 (1.00-1.06)	0.347
M stage		<0.001		<0.001
M0	Reference		Reference
M1	5.15 (3.85-6.90)		4.09 (3.04-5.51)	<0.001
Mx	2.77 (0.80-9.59)		2.31 (0.65-8.25)	0.197
Histology grade		<0.001		<0.001
Well differentiated	Reference		Reference
Moderately differentiated	1.11 (0.84-1.46)		0.95 (0.72-1.26)	0.728
Poorly differentiated	5.12 (3.14-8.35)		3.90 (2.39-6.36)	<0.001
Undifferentiated	3.84 (1.43-10.33)		4.18 (1.51-11.57)	0.006
Unknown	1.33 (0.98-1.79)		1.38 (1.01-1.87)	0.041

^aContinuous variables.