Protective Role of Somatostatin in Sepsis-Induced Intestinal Barrier Dysfunction through Inhibiting the Activation of NF-κB Pathway

Figure 1

SST prevented sepsis-induced intestinal barrier dysfunction. (a) Intestinal tissue from the control, sham, model, and model+SST group was detected using hematoxylin and eosin (HE) staining. Sections presented ten mice in each group. Magnification: 100x. Scale bar: 200 μm. (b) TER of gut mucosae was evaluated via transepithelial voltohmmeter. (c) The specific somatostatin receptor subtype SSTR5 was detected by qRT-PCR. (d–f) Detection of inflammatory factors, including TNF-α, IL-6, and IL-10 in the ileum using ELISA. Data were shown as the from 3 independent experiments. , vs. sham; ^###, vs. model. TNF-α: tumor necrosis factor α; IL-6: interleukin 6; IL-10: interleukin 10; SST: somatostatin.

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