S100A12 in Digestive Diseases and Health: A Scoping Review

Figure 1

Model of S100A12 structure. (a) indicates PHYRE prediction of S100A12 secondary and tertiary structure. (b) indicates the primary structure beginning with helix 1 at the N terminus (pictured above in orange), calcium-binding loop 1 (pictured in yellow-orange), helix 2 (pictured in yellow), helix 3 (pictured in green), calcium-binding loop 2 (pictured in turquoise), and helix 4 (pictured in blue). The metal-binding residues which comprise the dimer interface are highlighted in red in the primary structure sequence. The two EF-hand motifs, similar in structure to a thumb and forefinger, are pictured in orange/yellow and green/blue, respectively. Metal-binding residues are highlighted in red.

(a)

(b)