Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis

Table 3

Multivariate analysis of prognostic factors.

Prognostic factors	OS		DFS
	Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Age	1.713 (1.154, 2.543)	0.008	1.474 (1.014, 2.145)	0.042
Tumor location		0.053		0.022
L	1		1
M	0.669 (0.392, 1.143)	0.141	0.617 (0.369, 1.032)	0.066
U	1.526 (0.823, 2.832)	0.180	1.148 (0.630, 2.093)	0.652
GEJ	1.100 (0.491, 2.465)	0.818	1.192 (0.564, 2.519)	0.645
Diffuse	1.759 (0.993, 3.118)	0.053	1.919 (1.117, 3.297)	0.018
Tumor size (cm)	1.772 (1.102, 2.849)	0.018	1.556 (0.996, 2.430)	0.052
ypT		0.644		0.438
0	1		1
1-2	1.204 (0.138, 10.500)	0.867	1.384 (0.167, 11.434)	0.763
3-4	1.954 (0.212, 17.971)	0.554	2.340 (0.281, 19.514)	0.432
ypN		0.005		0.011
0	1		1
1	5.104 (1.733, 15.027)	0.003	3.317 (1.345, 8.184)	0.009
2	4.882 (1.618, 14.730)	0.005	3.600 (1.426, 9.088)	0.007
3	7.641 (2.404, 24.283)	0.001	5.200 (1.949, 13.869)	0.001
ypTNM	0.842 (0.266, 2.663)	0.769	0.747 (0.283, 1.974)	0.557
Histological type	0.934 (0.631, 1.382)	0.731	0.879 (0.605, 1.276)	0.498
Lauren classification	1.433 (0.942, 2.181)	0.093	1.334 (0.900, 1.979)	0.152
Grade of differentiation	1.620 (0.849, 3.093)	0.143	1.666 (0.915, 3.032)	0.095
Vascular or lymphatic invasion	1.739 (1.166, 2.592)	0.007	1.465 (1.002, 2.144)	0.049
Nervous invasion	0.966 (0.645, 1.447)	0.866	0.981 (0.668, 1.441)	0.924
Mandard TRG	1.429 (0.797, 2.561)	0.231	1.430 (0.836, 2.443)	0.191
Adjuvant treatment	2.556 (1.486, 4.396)	0.001	2.556 (1.531, 4.270)	0.001