Gastroenterology Research and Practice

Research Article

Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis

Table 1

Comparison of characteristics of cirrhotic patients without and with decompensating events.


Variables	Without decompensation		With decompensation		value
Variables	No. Pts	; median (range) or frequency (percentage)	No. Pts	; median (range) or frequency (percentage)	value

Sex (male/female), (%)	42	35 (83.33%)/7 (16.67%)	134	89 (66.42%)/45 (33.58%)	0.051
Age (years)	42	; 52.5 (46.50-62.25)	134	; 55.00 (47.00-65.00)	0.130
Causes of liver diseases, (%)	42		134
Hepatitis B virus alone	14	14 (33.33%)	48	48 (35.82%)	/
Hepatitis C virus alone	4	4 (9.52%)	9	9 (6.72%)	/
Alcohol alone	12	12 (28.57%)	29	29 (21.64%)	/
Hepatitis B virus+alcohol	1	1 (2.38%)	4	4 (2.99%)	/
Autoimmune	1	1 (2.38%)	16	16 (11.94%)	/
Drug	1	1 (2.38%)	6	6 (4.48%)	/
Others	1	1 (2.38%)	0	0 (0%)	/
Red blood cell (10¹²/L)	42	; 4.05 (3.62-4.57)	134	; 3.10 (2.56-3.76)	<0.001
Hemoglobin (g/L)	42	; 123.00 (108.00-131.25)	134	; 91.50 (70.00-115.00)	<0.001
Hematocrit (%)	42	; 36.60 (32.88-39.63)	134	; 28.20 (21.90-34.73)	<0.001
White blood cell (10⁹/L)	42	; 3.35 (2.45-4.65)	134	; 3.70 (2.60-6.03)	0.155
Platelet count (10⁹/L)	42	; 71.00 (48.50-104.75)	134	; 76.00 (53.50-107.50)	0.433
Total bilirubin (μmol/L)	42	; 22.90 (16.15-32.45)	134	; 23.15 (15.15-45.13)	0.682
Direct bilirubin (μmol/L)	42	; 9.90 (6.25-13.75)	134	; 10.50 (6.08-20.73)	0.351
Alanine aminotransferase (U/L)	42	; 26.29 (17.86-37.58)	134	; 23.43 (15.80-38.64)	0.391
Aspartate aminotransferase (U/L)	42	; 32.73 (24.25-50.47)	134	; 32.71 (23.91-59.55)	0.753
Alkaline phosphatase (U/L)	42	; 96.34 (77.34-139.58)	134	; 95.93 (67.99-143.13)	0.612
Gamma-glutamyl transpeptidase (U/L)	42	; 49.94 (27.53-83.88)	134	; 41.56 (19.87-93.42)	0.429
Albumin (g/L)	42	; 37.35 (32.38-41.03)	134	; 30.80 (25.60-35.80)	<0.001
Blood urea nitrogen (mmol/L)	42	; 4.87 (3.79-6.19)	134	; 6.05 (4.39-7.87)	0.007
Creatinine (μmol/L)	42	; 64.68 (56.02-74.81)	134	; 65.20 (53.53-78.15)	0.694
eGFR (mL/min/1.73 m²)	42	; 118.40 (97.75-133.97)	134	; 106.52 (84.22-133.52)	0.068
Na (mmol/L)	42	; 139.45 (137.80-140.43)	134	; 138.45 (136.00-141.00)	0.226
Prothrombin time (second)	42	; 16.05 (15.03-16.88)	134	; 16.70 (15.10-18.90)	0.033
Activated partial thromboplastin time (second)	42	; 41.60 (38.98-45.53)	134	; 40.15 (37.10-44.30)	0.149
International normalized ratio	42	; 1.28 (1.19-1.38)	134	; 1.36 (1.20-1.58)	0.040
D-dimer (mg/L)	41	; 0.60 (0.29-1.27)	131	; 1.81 (0.72-4.41)	<0.001
High-sensitivity C-reactive protein (mg/L)	41	; 2.20 (0.90-6.60)	133	; 5.70 (1.35-14.10)	0.016
MELD score	42	; 10.26 (9.04-13.06)	134	; 11.32 (9.22-16.56)	0.093
Child-Pugh score	42	; 6.00 (5.00-6.00)	134	; 7.00 (6.00-9.00)	<0.001
Child-Pugh class	42		134
A, (%)	33	33 (78.57%)	44	44 (32.84%)	<0.001
B, (%)	9	9 (21.43%)	58	58 (43.28%)	<0.001
C, (%)	0	0 (0%)	32	32 (23.88%)	<0.001
NT-pro BNP (pg/mL)	38	; 41.86 (20.36-69.16)	120	; 140.75 (62.34-401.33)	<0.001
High-sensitivity cardiac troponin T (ng/mL)	42	0; 0.006 (0.003-0.008)	128	; 0.008 (0.015-0.003)	0.007
Creatine kinase (U/L)	42	; 84.00 (53.50-123.75)	132	; 71.00 (44.00-105.50)	0.157
Creatine kinase MB (U/L)	42	; 33.00 (19.00-47.25)	132	; 29.5 (19.25-46.25)	0.604
Lactate dehydrogenase (U/L)	42	; 173.50 (137.50-211.50)	132	; 185.00 (152.00-226.75)	0.281

Bold font indicates statistically significant values. Abbreviations: eGFR: the estimated glomerular filtration rate; MELD: model for end-stage liver disease; NT-pro BNP: N-Terminal pro-B-type natriuretic peptide.