Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients

Table 1

Main features of cases (patients with HCC) and controls (patients with chronic liver disease, free of HCC). Continuous variables are presented as medians [interquartile range], categorical variables as frequencies (%).

	HCC (yes)	HCC (no)	value
Age, years	74 [69-78]	74 [68-77]	0.208
Male gender, (%)	67 (61)	201 (61)	0.788
Body mass index (kg/m^2)	25 [23-28]	25 [22-29]	0.673
Diabetes, (%)	28 (25)	53 (16)	0.033
History of alcohol abuse, (%)	25 (23)	39 (12)	0.008
HBsAg, positive (%)	3 (3)	4 (1)	0.374
AST (U/L)	63 [43-93]	51 [34-87]	0.040
ALT (U/L)	54 [34-85]	56 [32-88]	0.633
Liver stiffness (kPa)	15.9 [12.0-21.8]	10.7 [6.8-16.6]	<0.001
AST to platelet ratio index	1.36 [0.78-2.11]	0.87 [0.45-1.61]	<0.001

Abbreviations: HCC: hepatocellular carcinoma; HCV: hepatitis C virus; HBsAg: hepatitis B virus surface antigen; AST: aspartate aminotransferase; ALT: alanine aminotransferase.