Review Article
Claudin-1 Is a Valuable Prognostic Biomarker in Colorectal Cancer: A Meta-Analysis
Table 1
Main characteristics of the included publications.
| | First author | Year | Country | No. of patients | Site | Mean age (years) | TNM stage | Follow-up (months) | Claudin-1 expression | Detection method | Antibody | Cutoff value | High expression | Outcome | NOS (score) | Data extraction method |
| | Karabulut | 2015 | Turkey | 140 | Colorectal | 60.0 | I-IV | 14.0 | Serum | ELISA | YHB0737HU | >8.4 ng/ml | 50.0% | OS/DFS | 7 | K-M method | | Matsuoka | 2011 | Japan | 156 | Colorectal | 65.0 | II-IV | 79.0 | Protein | IHC | E3411 | % | 20.5% | OS/DFS | 8 | Univariate | | Nakagawa | 2011 | Japan | 119 | Colorectal | NR | I-IV | 46.8 | mRNA | RT-PCR | NR | | 50.0% | OS/DFS | 8 | K-M method | | Resnick | 2005 | USA | 129 | Colon | 72.5 | II | 96.0 | Protein | IHC | Polyclonal rabbit | | 24.8% | OS/DFS | 9 | K-M method | | Shibutani | 2013 | Japan | 344 | Colorectal | 66.8 | II-III | 51.7 | Protein | IHC | Polyclonal rabbit | % | 68.0% | OS/DFS | 9 | K-M method | | Singh | 2011 | USA | 250 | Colon | 64.6 | I-IV | 46.1 | Protein | IHC | Anti-claudin1 | >median | 50.0% | OS | 6 | K-M method | | Yoshida | 2011 | Japan | 306 | Rectum | 64.0 | II-III | 38.0 | Protein | IHC | Monoclonal antibodies | % | 46.7% | OS/DFS | 8 | K-M method | | Kim | 2019 | Korea | 260 | Colon | 63.5 | I-IV | NR | Protein | IHC | Anti-claudin-1 | | 57.3% | OS/DFS | 8 | K-M method |
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NR: not reported; IHC: immunohistochemistry; RT-PCR: reverse transcriptase polymerase chain reaction; SI: staining intensity; PP: positive cell percentage; ; OS: overall survival; DFS: disease-free survival; K-M: Kaplan-Meier; NOS: Newcastle Ottawa Scale. |
