Mouse Models of Nonalcoholic Steatohepatitis: Head-to-Head Comparison of Dietary Models and Impact on Inflammation and Animal Welfare

Table 1

Design of score sheet.

Parameter		Score
General state
Body weight		1
	Weight reduction 5-10%	5
	Weight reduction 11-20%	10
	Weight	20
Fur	Fur faulty (reduced body hygiene)	1
	Fur lusterless and disheveled	5
	Fur dirty	10
Stoma	Scruffy	1
	Sticky or moist	5
Eyes	Turbid	5
Behavior
Nutrition	Hypophagia	5
	Fasting	10
Activity	Limited motor function or hyperkinetic	5
	Ducked posture, lethargy, coordination disorder	10
Social behavior	Self-isolation	5
	Missing fight-or-flight response	10
	Self-amputation (automutilation)	20
Clinical results
Digestion	Diarrhea	5
	Steatorrhea	5
Temperature, pulse, and respiration	Variation of temperature 1–2°C, respiration, and pulse ±30%	5
	Variation of , respiration, and pulse ±50%	20
Vegetative symptoms	Shivering	10
Trial-specific indicators	Edema	20
	Ascites	20
	Jaundice	20