Comparison of Platelet-Rich Plasma-Impregnated Suture Material with Low and High Platelet Concentration to Improve Colonic Anastomotic Wound Healing in Rats
Table 2
Comparison of parameters in study groups.
Median (range)
Control ()
L-PRP ()
H-PRP ()
value
Body weight (g)
Preoperative
277.50 (50.00)
277.50 (40.00)
280.00 (45.00)
0.997
Postoperative 7th day
280.00 (55.00)
275.00 (35.00)
272.50 (35.00)
0.865
Wound healing injury score
Necrosis
1.00 (1.00)
0.00 (2.00)
1.50 (2.00)
0.056
PMN cell infiltration
2.00 (1.00)
2.00 (1.00)
2.00 (2.00)
0.724
MN cell infiltration
2.00 (0.00)
2.00 (0.00)
2.00 (1.00)
0.417
Edema
2.00 (1.00)
1.00 (0.00)
0.00 (0.00)
<0.001
Mucosal epithelium
3.00 (1.00)q
2.50 (1.00)q
1.00 (2.00)
0.013
Submucosal/mucosal muscle layer
3.00 (0.00)
3.00 (2.00)
3.00 (0.00)
0.159
Granulation tissue
3.00 (1.00)
2.00 (1.00)
2.00 (1.00)
0.002
Total score
15.50 (4.00)
13.00 (7.00)
11.50 (6.00)
0.007
ABP (mmHg)
121.00 (57.00)
180.00 (49.00),qqq
124.00 (62.00)
0.001
Hydroxyproline (μg/mg tissue)
0.25 (0.17)
0.56 (0.37),q
0.39 (0.10)
0.001
ABP: anastomotic bursting pressure; PMN: polymorphonuclear; MN: mononuclear. ,, and compared to control; q,qq, and qqq compared to HRP. Kruskal-Wallis test with post hoc Tamhane’s test.
