Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis

Table 1

Main characteristics of studies for diagnosis analysis.

Study	Year	circRNA	Cancer type	Sample num		Method	Regulation	Diagnosis power
				Case	Control			Sen.	Spe.	AUC.
Rong et al. [22]	2018	circ-DLG1	EC	35	28	qRT-PCR	Upregulated	82.86%	50.00%	0.648
Fan et al. [19]	2018	circ_0062459	EC	50	50	qRT-PCR	Downregulated	64.00%	92.00%	0.836
	2018	circ_0001946	EC	50	50	qRT-PCR	Downregulated	92.00%	80.00%	0.894
Wang (1) et al. [24]	2019	circ-TTC17	EC	30	25	qRT-PCR	Upregulated	73.33%	88.00%	0.82
Zhang et al. [25]	2019	circ-SMAD7	EC	32	25	qRT-PCR	Upregulated	78.13%	96.00%	0.859
Hu et al. [20]	2019	circ-GSK3β	EC	43	53	qRT-PCR	Upregulated	68.75%	81.25%	0.793
Wang (2) et al. [23]	2020	circ-SLC7A5	EC	87	53	qRT-PCR	Upregulated	67.82%	79.25%	0.772
Huang et al. [21]	2020	circ_0004771	EC	105	105	qRT-PCR	Upregulated	71.43%	81.90%	0.816

AUC, area under ROC curve; qRT-PCR, quantitative real-time polymerase chain reaction; Sen, sensitivity; Spe., specificity; EC, esophageal cancer; circRNA, circular RNA.