Research Article

Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis

Table 1

Characteristics of patients in the training and validation groups.

CharacteristicTraining group ()Validation group ()
Nonmetastasis ()Metastasis ()Nonmetastasis ()Metastasis ()

Gender<0.001<0.001
 Female1,965 (49.01%)342 (41.30%)979 (49.05%)166 (39.24%)
 Male2,044 (50.99%)486 (58.70%)1,017 (50.95%)257 (60.76%)
Age (years)0.3220.919
 ≤40227 (5.66%)57 (6.88%)125 (6.26%)27 (6.38%)
 41-55870 (21.70%)196 (23.67%)431 (21.59%)89 (21.04%)
 56-701,584 (39.51%)292 (35.27%)754 (37.78%)165 (39.01%)
 >701,328 (33.13%)283 (34.18%)686 (34.37%)142 (33.57%)
Race0.0570.475
 White2,701 (67.37%)586 (70.77%)1,373 (68.79%)290 (68.56%)
 Black751 (18.73%)141 (17.03%)345 (17.28%)85 (20.09%)
 Others526 (13.12%)97 (11.71%)264 (13.23%)47 (11.11%)
 NOS31 (0.77%)4 (0.48%)14 (0.70%)1 (0.24%)
Insurance<0.0010.312
 Yes3,107 (77.50%)586 (70.77%)1,533 (76.80%)313 (74.00%)
 No116 (2.89%)33 (3.99%)56 (2.81%)17 (4.02%)
 NOS786 (19.61%)209 (25.24%)407 (20.39%)93 (21.99%)
Marital status0.9170.922
 Married2,306 (57.52%)465 (56.16%)1,148 (57.52%)242 (57.21%)
 Unmarried1,484 (37.02%)331 (39.98%)749 (37.53%)160 (37.83%)
 NOS219 (5.46%)32 (3.86%)99 (4.96%)21 (4.96%)
Tumor location0.0090.032
 Large intestine216 (5.39%)35 (4.23%)94 (4.71%)11 (2.60%)
 Peritoneum78 (1.95%)34 (4.11%)47 (2.35%)18 (4.26%)
 Stomach2,599 (64.83%)468 (56.52%)1,306 (65.43%)253 (59.81%)
 Small intestine1,093 (27.26%)289 (34.90%)535 (26.80%)139 (32.86%)
 Esophagus23 (0.57%)2 (0.24%)14 (0.70%)2 (0.47%)
Pathologic grade<0.001<0.001
 I641 (15.99%)35 (4.23%)307 (15.38%)13 (3.07%)
 II451 (11.25%)43 (5.19%)214 (10.72%)25 (5.91%)
 III147 (3.67%)56 (6.76%)76 (3.81%)19 (4.49%)
 IV195 (4.86%)78 (9.42%)87 (4.36%)45 (10.64%)
 NOS2,575 (64.23%)616 (74.40%)1,312 (65.73%)321 (75.89%)
Tumor size (cm)<0.001<0.001
 ≤2495 (12.35%)16 (1.93%)221 (11.07%)9 (2.13%)
 2-51,230 (30.68%)109 (13.16%)644 (32.26%)48 (11.35%)
 5-101,241 (30.96%)223 (26.93%)629 (31.51%)108 (25.53%)
 >10833 (20.78%)307 (37.08%)389 (19.49%)154 (36.41%)
 NOS210 (5.24%)173 (20.89%)113 (5.66%)104 (24.59%)
Lymph nodes<0.001<0.001
 Negative3,783 (94.36%)548 (66.18%)1,884 (94.39%)306 (72.34%)
 Positive94 (2.34%)123 (14.86%)62 (3.11%)49 (11.58%)
 NOS132 (3.29%)157 (18.96%)50 (2.51%)68 (16.08%)
Extension<0.001<0.001
 Mild3,051 (76.10%)280 (33.82%)1,565 (78.41%)145 (34.28%)
 Grievous726 (18.11%)346 (41.79%)347 (17.38%)156 (36.88%)
 NOS232 (5.79%)202 (24.40%)84 (4.21%)122 (28.84%)
Mitotic count<0.001<0.001
 ≤5/50 HPF1,513 (37.74%)130 (15.70%)750 (37.58%)69 (16.31%)
 >5/50 HPF1,615 (40.28%)432 (52.17%)788 (39.48%)202 (47.75%)
 NOS881 (21.98%)266 (32.13%)458 (22.95%)152 (35.93%)

NOS: not otherwise specified.