Novel Pathologic Factors for Risk Stratification of Gastric “Indefinite for Dysplasia” Lesions

Table 4

Interpretation of results of pathologic factors for predicting carcinoma by two pathologists.

			Pathologist1			Pathologist2			Cohen’s Kappa coefficients
			Noncarcinoma ()	Carcinoma ()		Noncarcinoma ()	Carcinoma ()
Effectible factors	Neutrophils	≤mild	34	10	0.408	1	0	0.75	0.959
		≥moderate	38	14		74	24
	Ulcer	Absent	41	17	0.168	43	17	0.234	0.956
		Present	31	7		29	7
	Intestinal metaplasia	<50%	65	24	0.124	68	24	0.31	0.712
		≥50%	7	0		4	0
Structural atypia	Loss of surface maturation	Absent	37	3	0.001	42	7	0.012	0.813
		Present	35	21		30	17
	Margination	Absent	61	19	0.364	62	19	0.304	0.731
		Present	11	5		10	5
	Cribriform	Absent	58	9	<0.001	65	14	0.001	0.664
		Present	14	15		7	10
	Branching/budding	Absent	67	13	<0.001	70	17	0.001	0.682
		Present	5	11		2	7
	Arrangement	Regular	40	3	<0.001	44	6	0.002	0.855
		Irregular	32	21		28	18
	Crowding	Absent	43	5	0.001	45	11	0.116	0.833
		Present	29	19		27	13
		No	56	5	<0.001	55	4	<0.001	0.956
		Yes	16	19		17	20
Nuclear atypia	Loss of nuclear polarity	Absent	48	8	0.004	51	11	0.026	0.869
		Present	24	16		21	13
	Pseudostratification	<half	39	7	0.029	43	13	0.403	0.793
		≥half	33	24		29	11
	Pleomorphism	Absent	65	20	0.279	67	21	0.318	0.825
		Present	7	4		5	3
	Hyperchromasia or vesicular	Absent	2	0	0.561	4	2	0.469	0.484
		Present	70	24		68	22
	Prominent nucleoli	Absent	20	3	0.104	23	6	0.356	0.843
		Present	52	21		49	18

SAA: structural atypia area.