Novel Pathologic Factors for Risk Stratification of Gastric “Indefinite for Dysplasia” Lesions

Table 5

Multivariate analysis of pathologic factors for predicting final diagnosis.

		Predicting neoplasm		Predicting above HGD		Predicting carcinoma
		Pathologist1	Pathologist2	Pathologist1	Pathologist2	Pathologist1	Pathologist2
		dAUC	dAUC	dAUC	dAUC	dAUC	dAUC
Structural atypia	Loss of surface maturation	0.074	0.083	0.098	0.083	0.081	0.090
	Margination	0.012	0.019	0.000	0.019	0.013	0.000
	Cribriform	0.041	0.051	0.074	0.051	0.103	0.113
	Branching/budding	0.050	0.073	0.066	0.073	0.095	0.086
	Arrangement	0.027	0.038	0.094	0.038	0.115	0.102
	Crowding	0.021	0.065	0.039	0.065	0.042	0.095
		0.130	0.110	0.173	0.110	0.182	0.135
Nuclear atypia	Loss of nuclear polarity	0.007	0.024	0.064	0.024	0.080	0.083
	Pseudostratification	−0.036	0.019	0.027	0.019	0.005	0.057
	Pleomorphism	−0.068	−0.030	−0.079	−0.030	−0.016	0.010
	Hyperchromasia	−0.062	−0.016	−0.088	−0.016	−0.047	0.000
	Prominent nucleoli	−0.095	−0.036	−0.068	−0.036	0.002	0.041

dAUC: differences in area under curve; HGD: high-grade dysplasia; SAA: structural atypia area.