p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for TP53 Mutations in Gastrointestinal Neuroendocrine Neoplasms

Table 3

Comparison between p53 IHC patterns and TP53 mutation types in 92 GI-NEN cases.

IHC staining pattern	Mutation types
	LOF			Wild type	GOF
	Nonsense	Frameshift	Splicing		Missense	In-frame
Pattern A	5	3	3	2	0	0
Pattern B	1	0	1	33	0	0
Pattern C1	1	0	1	0	3	1
Pattern C2	1	1	0	3	29	4
Total	8	4	5	38	32	5