Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model

Figure 3

Upregulations of IL-1β, IL-4, IL-6, IL-17A, MCP-1, TNF-α, and IFN-γ in mucositis mice were shown after 5-FU injection. IL-6, IL-1β, and TNF-α serum levels were measured by the panel kit. (a) The serum IL-1β level in the 5-FU+Lcr35 group () was significantly lower than that in the 5-FU group () (). (b) The serum IL-4 level in the 5-FU+Lcr35 group () was significantly lower than that in the 5-FU group () (). (c) The serum IL-6 level in the 5-FU+Lcr35 group () was significantly lower than that in the 5-FU group () (). (d) The serum IL-17A level in the 5-FU+Lcr35 group () was significantly lower than that in the 5-FU group () (). (e) The serum MCP-1 level in the 5-FU+Lcr35 group () was significantly lower than that in the 5-FU group () (). (f) The serum TNF-α level in the 5-FU+Lcr35 group () was significantly lower than that in the 5-FU group () (). (g) The serum IFN-γ level in the 5-FU+Lcr35 group () was significantly lower than that in the 5-FU group () (). Statistical analyses were performed by one-way ANOVA.

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