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Study | Year | Region | Sample size | Study type | Mean age at diagnosis of IBD (year) | No. of patients with dysplasia and CRC | No. of IBD patients; UC, CD | Family history of CRC | Family history of IBD | Relevant degree | Proportions |
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Kisiel et al. [23] | 2012 | USA | 77 | Cohort: followed 77 IBD patients | 47.6 (14.2–83.2) | 31 | 77 UC patients under polypectomy | 12 | — | First | |
Bergeron et al. [24] | 2010 | France | 855 | Cohort: followed 855 IBD patients | 33 (19-47) | 14 with AL-LGDa | 28 | 2 | 1 | — | |
28 with CR-LGDb | 56 | 1 | 4 | — | |
33 with advanced neoplasia | 66 | 0 | 3 | — | |
Baars et al. [25] | 2011 | Netherlands | 565 | Case- (CRC with IBD) control (IBD) | 33 for cases, 31 for control | 173 (UC:113; CD: 58; unclassified: 2) | 392 (UC: 175; CD: 207; unclassified: 10) | 132 | — | 12 first, 11 second, 109 unknown | |
Rubin et al. [26]. | 2006 | USA | 125 | Case- (UC with developed dysplasia or CRC) control (UC without neoplasia) | 29.5 for cases, 30.5 for control | 26 | 96 | 9 | 6 | First | |
Lashner et al. [27] | 1999 | USA | 95 | Cohort: followed 95 UC patients | 26.5 for p53-positive, 29.5 for p53-negative | 36 | 95 | 1 | 3 | — | |
Askling et al. [8] | 2001 | Sweden | 8810 | Cohort: followed 8810 CD patients | — | 143 | 8810 | 256 | — | First, second, or more | |
Rutter et al. [29] | 2004 | England | 204 | Case- (CRC neoplasia) control (UC) | 33 for cases, 33 for controls | 68 | 136 | 18 | — | First | |
Wu et al. [28] | 2014 | USA | 44 | Cohort: followed 44 UC patients | 29.3 | 22 with LGD | 44 | — | 2 | First or second | |
28.2 | 43 with adenocarcinoma and pouch dysplasia | — | 4 | |
Freire et al. [30] | 2014 | Portugal | 76 | Cross-sectional in UC | 33.3 | — | 76 | 7 | — | — | |
Connelly et al. [31] | 2014 | USA | 82 | Case- (UC with dysplasia/CRC) control (UC without dysplasia/CRC) | 34.49 | 41 | 41 | 3 | 11 | — | |
Lutgens et al. [32] | 2015 | Netherlands | 530 | Case- (IBD-CRC) control (IBD) | 27.5 for cases, 25.5 for control | 188 | 342 | 18 | — | First | |
Rubin et al. [33] | 2013 | USA | 200 | Case- (CRC and UC) control (UC | 47.1 | 59 | 141 | 8 | — | First or second | |
Shinozaki et al. [34] | 1999 | Japan | 77 | Case- (UC with neoplasia) control (UC) | 34.3 for cases, 28.4 for control | 16 | 61 | 1 | — | First or second | |
Mooiweer et al. [35] | 2013 | Netherlands | 1018 | Cohort: followed 1018 IBD patients | 47.7 | 11 | 1018 | 32 | — | First | |
Velayos et al. [36] | 2006 | USA | 376 | Case- (UC with CRC) control (UC) | 25 for cases, 27 for control | 188 | 188 | 6 | — | First | |
Askling et al. [20] | 2001 | Sweden | 31093 | Cohort: followed 31093 IBD patients | 37.65 | 560 | 13186 | 234 | — | First, second or more | |
Eaden et al. [37] | 2000 | Sweden | 204 | Case- (UC, CRC) control (UC) | 57.4 at diagnosis of CRC | 102 | 102 | 2 | 5 | First | |
Bopanna et al. [38] | 2016 | India | 28 | Cross-sectional in UC | 28.89 | — | 28 | 0 | — | — | |
Parian et al. [39] | 2016 | USA | 187 | Cross-sectional in UC | 36.7 for UC with dysplasia, 29.7 for UC without dysplasia | 39 | 148 | 12 | 7 | First | |
Rini et al. [40] | 2008 | USA | 223 | Cross-sectional in IBD | 43.94 | — | 223: 136 UC, 55 CD, 32 unknown | 15 in first degree; 34 in second or more | — | First, second, or more | |
Tang et al. [21] | 2010 | USA | 48 | Case- (IBD with CRC) control (IBD) | 36.6 for cases, 34.7 for control | 18 | 30 | 3 | 3 | First, second, or more | |
Lakatos et al. [41] | 2006 | Hungary | 723 | Cohort: followed 723 UC | 49 | 13 | 723 | — | 0 | — | |
Lashner [42] | 1993 | USA | 67 | Case- (UC with dysplasia and CRC) control (UC) | — | 6 | 61 | 7 | 2 | — | |
Derikx et al. [43] | 2014 | Netherlands | 124 | Case- (IBD with carcinoma and dysplasia) control (IBD) | 25.7 for cases, 25.7 for control | 25 | 99 | 0 | — | — | |
Lashner et al. [22] | 1997 | USA | 98 | Case- (UC with CRC or dysplasia) control (UC without CRC or dysplasia) | 25.8 for CRC or dysplasia, 29.5 for no dysplasia | 29 | 69 | 1 | 1 | — | |
Brackmann et al. [19] | 2009 | Norway | 67 | Cohort: followed 67 IBD with CRC | 25 | 67 | 67 | 6 | 5 | First, second or more | |
Adams et al. [44] | 2013 | USA | 7202 | Cohort: followed 7202 CRC cases | — | 7202 | 250 | 35 | — | First | |
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