Pleckstrin-2 as a Prognostic Factor and Mediator of Gastric Cancer Progression

Figure 6

PLEK2 promotes EMT in gastric cancer cells. (a) The heat map shows the top 100 differentially expressed genes related to PLEK2. (b) Biological pathways enriched in genes that are more than 2-fold abundant in the PLEK2-high group compared to the PLEK2-low group. (c) Biological pathways enriched in genes that are more than 2-fold deficient in the PLEK2-high group compared to the PLEK2-low group. (d) PLEK2 overexpression induces hallmarks of EMT in gastric cancer cells, while PLEK2 knockdown inhibits EMT.

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