Research Article
TMEM100 Modulates TGF-β Signaling Pathway to Inhibit Colorectal Cancer Progression
Figure 4
TMEM100 suppresses CRC cell growth by regulating TGF-β signaling pathway. (a) The signaling pathway regulated by TMEM100 was analyzed by GSEA. (b) Western blot assessed the expression of TGF-β signaling-related proteins upon TMEM100 overexpression. The proliferative, colony formative, invasive, and migratory abilities of NCI-H498 cells were determined by conducting (c) MTT assay, (d) colony formation assay, (e) Transwell assay, and (f) scratch healing assay upon simultaneously overexpressing Smad2/Smad3 and TMEM100. Compared with oe-NC, ; #compared with oe-Smad2/Smad3, .
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