TMEM100 Modulates TGF-β Signaling Pathway to Inhibit Colorectal Cancer Progression

Figure 5

Mechanism diagram of TMEM100 inhibiting CRC. TMEM100 inhibits TGF-β activation by suppressing the interaction between TGF-β ligand and its homology type I and type II one-way transmembrane receptors, thereby inhibiting its Smad2/Smad3 phosphorylation. Ultimately, progression of CRC cells was hampered. Red circles represent phosphorylation. I and II represent TGF-β type I and type II receptors, respectively.