Predicting Individual Survival after Curative Esophagectomy for Squamous Cell Carcinoma of Esophageal

Table 3

Univariable and multivariable Cox analysis of prognostic factors for disease free survival in 503 patients with esophageal squamous cell carcinoma.

	Univariable analysis		Multivariable analysis
	HR (95% CI)	value	HR (95% CI)	value
Age, year	1.01 (0.99-1.02)	0.17
Sex
Male	Ref
Female	0.75 (0.54-1.02)	0.07
BMI, kg/m^2	0.97 (0.94-1.01)	0.20
Tobacco use
No	Ref
Yes	1.07 (0.84-1.36)	0.60
Alcohol use
No	Ref
Yes	1.12 (0.86-1.45)	0.42
Comorbidities
History of hypertension
No
Yes	1.11 (0.87-1.41)	0.42
History of diabetes
No	Ref
Yes	1.26 (0.96-1.64)	0.09
History of COPD
No	Ref		Ref
Yes	1.42 (1.02-1.97)	0.04	1.65 (1.17-2.31)	0.004
History of hepatitis
No	Ref
Yes	0.96 (0.69-1.33)
History of cardiovascular disease
No	Ref
Yes	0.91 (0.66-1.26)
Preoperative albumin	0.96 (0.93-0.99)	0.04
Preoperative platelet, 10^9	1.001 (0.999-1.003)	0.436
Preoperative WBC, 10^9	1.05 (0.99-1.12)	0.08
Preoperative NLR	1.05 (0.99-1.11)	0.05
Length of tumor, cm	1.17 (1.11-1.25)	<0.001
Location of tumor
Upper	Ref
Middle	0.85 (0.62-1.17)	0.33
Lower	0.93 (0.65-1.35)	0.71
Differentiation of tumor
Well	Ref
Moderate	1.62 (1.07-2.46)	0.02
Poor	2.04 (1.31-3.18)	0.002
Pathological T stage
T1	Ref		Ref
T2	2.92 (1.67-5.09)	<0.001	2.21 (1.25-3.89)	0.006
T3	5.23 (3.08-8.89)	<0.001	3.46 (2.00-5.97)	<0.001
T4	6.42 (3.48-11.82)	<0.001	3.47 (1.82-6.60)	<0.001
Pathological N factor
N0	Ref		Ref
N1	2.09 (1.58-2.78)	<0.001	1.65 (1.30-2.49)	0.002
N2	3.72 (2.37-5.84)	<0.001	2.20 (1.27-3.79)	0.005
N3	5.11 (3.68-7.09)	<0.001	3.20 (2.07-4.93)	<0.001
Pathological stage
I	Ref
II	2.80 (1.63-4.81)	<0.001
III	7.23 (4.19-12.46)	<0.001
IV	7.02 (3.96-12.45)	<0.001
Number of dissected LNs	1.01 (0.99-1.02)	0.28
Number of positive LNs	1.13 (1.10-1.17)	<0.001
Rate of positive LNs	9.19 (5.8-14.58)	<0.001	1.99 (0.90-4.36)	0.009
Postoperative complications
Postoperative pulmonary complications	1.21 (0.94-1.56)	0.14
Postoperative anastomotic leakage	1.44 (0.88-2.35)	0.15
Postoperative cardiovascular disease	1.11 (0.84-1.47)	0.46
Sepsis	1.66 (1.07-2.57)	0.02	1.79 (1.16-2.79)	0.009

BMI: body mass index; COPD: chronic obstructive pulmonary disease; NLR: neutrophil to lymphocyte ratio.