lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression

Figure 3

GALNT8 as the oncogenic operator of GAU1 in CRC. (a) Correlation analysis of GALNT8 and GAU1 in 184 TCGA CRC samples (Spearman , ), and 66 frozen CRC tissues (qRT-PCR, , ). (b) qRT-PCR analysis of GALNT8 expression level in 66 paired CRC tissues and adjacent normal tissues (). N: adjacent normal tissues; T: tumor tissues. (c) Kaplan-Meier analysis of GALNT8 and overall survival in 66 CRC patients. (Kaplan-Meier ). (d) Representative photomicrographs of GALNT8 in CRC specimen TMA (magnification: ×100, ×400). (e) Two paired tumor-adjacent control representative cases of GALNT8 expression in the TMA (magnification: ×100, ×400). (f) Kaplan-Meier analysis of GALNT8 expression and overall survival in 69 TMA samples. (Kaplan-Meier ). (g) qRT-PCR and western blot analysis of GAU1 expression in the five CRC cell lines and the normal NCM460 cells was tested. . (h) qRT-PCR and western blot analysis of GALNT8 expression level in GAU1-overexpressed SW620 and HCT116 cells, as well as (i) GAU1-knockdown DLD1 and LoVo cells. .

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