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| Study | Country | No. patients (FMT/control) | Severity | Donor | Delivery route | Frequency | Dosage | Preantibiotic | Bowel lavage | Control intervention | Time of evaluation | Combined clinical and endoscopic improvement | Clinical remission | Endoscopic remission/response | Combined clinical remission and endoscopic remission/response (FMT/control) | Clinical remission (FMT/control) | Endoscopic remission (FMT/control) | Serious adverse events (FMT/control) |
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Costello
2019 | Australia | 38/35 | Mild to moderate (Mayo score 3-10, with endoscopic ) | Healthy volunteers (pooled 3-4 donors’ stool) | 1 colonoscopy, 2 enemas | 3 times over 7 days | Total stool weight 100 g | No | Yes | Autologous FMT | Week 8 | A total , with endoscopic | | | 12/3 | 18/6 | 4/0 | 3/2 |
Crothers
2018 | USA | 7/8 | Mild to moderate (Mayo score: 4-10) | Healthy volunteers with high stool butyrate (pooled 2 donors’ stool) | Daily FMT capsules | Daily | Capsule 0.375 g stool per time | Yes | Yes | Placebo | Week 12 | A total , with decrease in Mayo endoscopic | | Decrease in Mayo endoscopic | 3/0 | 2/1 | 3/0 | 0/0 |
Paramsothy
2017 | Australia | 41/40 | Mild to moderate (Mayo score: 4-10) | Healthy volunteers (pooled 3-7 donors’ stool) | 1 colonoscopy, 40 enemas | 1 colonoscopic infusion, followed by enemas 5 days per week for 8 weeks | 37.5 g stool per time, 150 ml infusion volume | No | Yes | Placebo | Week 8 | A total , with all and reduction in endoscopic | | Mayo endoscopic | 11/3 | 18/8 | 5/3 | 2/1 |
Rossen
2015 | Netherland | 23/25 | Mild to moderate (SCCAI 4–11, with endoscopic ) | Healthy partners, relatives, or volunteers (single donor’s stool) | 2 naso-duodenal infusions | 2 times at week 0 and week 3 | 500 ml | Yes | Yes | Autologous FMT | Week 12 | , decrease in Mayo endoscopic | | Mayo endoscopic | 7/5 | 7/8 | 2/2 | 2/2 |
Moayyedi
2015 | Canada | 38/37 | Mild to moderate (, with ) | Healthy volunteers (single donor’s stool) | 6 retention enemas | Once per week for 6 weeks | 50 g, 300 ml | NR | NR | Placebo | Week 7 | A full and endoscopic | | Mayo endoscopic | 9/2 | 15/9 | 9/3 | 3/2 |
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