Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain

Table 3

Clinical trials of FMT involving in nervous and mental disease.

NCT number	Conditions	FMT route	Phases	Status	Locations
NCT02255617	Hepatic encephalopathy	Colonoscopy & enema	Phase 1, phase 2	Completed	Canada
NCT02636647	Hepatic encephalopathy	Enema	Phase 1	Completed	United States
NCT03420482	Hepatic encephalopathy	Capsules	Phase 2	Recruiting	United States
NCT03152188	Hepatic encephalopathy	Capsules	Phase 1	Completed	United States
NCT03439982	Hepatic encephalopathy	Colonoscopy & enema	Phase 1, phase 2	Recruiting	Canada
NCT03796598	Hepatic encephalopathy	Capsules & enema	Phase 1, phase 2	Recruiting	United States
NCT03408886	Autism spectrum disorder	Pill (no detail)	Phase 2	Recruiting	United States
NCT03426826	Autism spectrum disorder	Gastroscope	Phase 1	Recruiting	United States
NCT03829878	Autism spectrum disorder	Capsules	Phase 2	Not yet recruiting	United States
NCT04182633	Autism spectrum disorder	Oral administration of FM (no detail)	Phase 2	Recruiting	United States
NCT04246398	Children with autism	Capsules	Not applicable	Not yet recruiting	Israel
NCT03026231	Parkinson’s disease	Capsules	Phase 1, phase 2	Withdrawn	United States
NCT03671785	Parkinson disease	Capsules	Phase 1	Recruiting	United States
NCT03808389	Parkinson disease	Nasojejunal	Not applicable	Recruiting	Belgium
NCT03876327	Parkinson disease	Not applicable	Phase 2, phase 3	Completed	Israel
NCT03183869	Multiple sclerosis	Enema	Phase 2	Terminated	Canada
NCT03594487	Multiple sclerosis	Colonoscopy	Phase 1	Recruiting	United States
NCT03975413	Multiple sclerosis	Not applicable	Not applicable	Active, not recruiting	United States
NCT04203017	Multiple sclerosis	Capsules	Phase 1	Recruiting	Russian Federation
NCT03691987	Chronic fatigue syndrome/myalgic encephalomyelitis	Enema	Phase 2	Recruiting	Norway
NCT04158427	Chronic fatigue syndrome/myalgic encephalomyelitis	Colonoscopy	Not applicable	Enrolling by invitation	Finland
NCT03233100	Depressive symptoms, anxiety symptoms, gut-brain disorders	Not applicable	Not applicable	Unknown status	China
NCT03281044	Major depressive disorder	Capsules	Phase 2	Terminated	Switzerland
NCT04001439	Depression in schizophrenia	Capsules	Not applicable	Not yet recruiting	France
NCT03998423	Alzheimer disease	Capsules	Phase 1	Terminated	United States
NCT02889627	Epilepsy	Microbiota suspension infused into midgut or lower gut (no detail)	Phase 2, phase 3	Recruiting	China
NCT03279224	Bipolar depression	Colonoscopy	Phase 2, phase 3	Recruiting	Canada
NCT03766321	Amyotrophic lateral sclerosis	Nasojejunal	Not applicable	Recruiting	Italy
NCT04132427	Pitt-Hopkins syndrome	Oral (no detail)	Phase 2	Recruiting	United States
NCT03416751	Alcohol abuse	Enema	Phase 1	Completed	United States
NCT03928808	Anorexia nervosa	Nasogastric tube	Early phase 1	Suspended	United States
NCT02336789	Disorientation as to people, time and place	Colonoscopy	Not applicable	Unknown status	Israel
NCT04014413	Hepatic encephalopathy, multiple sclerosis, autism, alcohol dependence	Not applicable	Not applicable	Recruiting	China

Study has passed its completion date, and status has not been verified in more than two years. Date from https://clinicaltrials.gov/.