Prognostic Value of TRPM7 Expression and Factor XIIIa-Expressing Tumor-Associated Macrophages in Gastric Cancer

Table 3

Effect of prognostic parameters on recurrence risk according to multivariate Cox regression analysis.

Prognostic parameters	Overall survival (multivariate)
	HR (95% CI)	value
Gender (male/female)	1.29 (0.93–1.78)	0.119
Age (<60, ≥60)	1.06 (0.78–1.44)	0.696
Site (proximal/middle/distal/diffuse)	0.99 (0.85-1.14)	0.892
Histological grade (1/2/3)	1.28 (1.01-1.64)	0.041
Lymphovascular invasion (absent/present)	1.09 (0.78-1.51)	0.604
Depth of invasion (pT1/pT2/pT3/pT4)	0.81 (0.63-1.05)	0.126
Lymph node metastasis (absent/1-2/3-6/≥7)	1.04 (0.84-1.29)	0.694
TNM stage (I/II/III/IV)	3.07 (2.26-4.18)	<0.001
CD4^+ TIL density (low/high)	0.55 (0.24-1.26)	0.162
CD8^+ TIL density (low/high)	0.23 (0.13-0.40)	<0.001
Factor XIIIa^+ TAM density (low/high)	1.26 (0.57-2.80)	0.557
TRPM7 expression (low/high)	4.57 (2.93-7.12)	<0.001

HR: hazard ratio; CI: confidence interval.