Study of the Mechanism by Which Curcumin Cooperates with Sestrin2 to Inhibit the Growth of Pancreatic Cancer

Figure 3

Curcumin synergistically enhances the antitumor proliferation effect of sestrin2. The changes in the proliferation ability of the PANC-1-sestrin2 overexpression group (sestrin2+) and sestrin2+/curcumin group (a); the cloning counts are presented in the form of a histogram (b). The changes in the proliferation ability of the CFPAC-1-sestrin2 overexpression group (sestrin2+) and sestrin2+/curcumin group (c); the cloning counts are presented in the form of a histogram (d); data are represented as the (). compared with control groups, compared with control groups, and ^## compared with sestrin2+ group; the CCK-8 assay was utilized to observe the change in the proliferation ability between the sestrin2+ group, sestrin2+/curcumin group, control group, and blank group in PANC-1 and CFPAC-1 cells (e, f).

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