A Comprehensive Review of Infectious Granulomatous Diseases of the Gastrointestinal Tract

Table 4

Comparison of histological features between Mycobacterium tuberculosis, Yersinia, and Crohn’s disease [2, 75].

Histopathological features	Tuberculosis	Yersinia spp.	Crohn’s disease
Number of granulomas	Numerous	Numerous	Few
Size of granulomas	Large (>200 μm)	Large	Small (<200 μm)
Other granuloma features:
(i) Caseating	Common	Few	Absent
(ii) Confluence	Common	Common	Absent
(iii) Prominent lymphoid cuff	Common	Common	Uncommon
(iv) Lymphoid hyperplasia	Common	Very common	Uncommon
(v) Architectural distortion	Common	Common	Common
(vi) Ulcers (deep and aphthous)	Common	Common	Common
(vii) Changes of chronicity unassociated with sites of granulomatous inflammation	Absent	Absent	Common
Multiple sites of involvement	Common	Rare	Common
Cobble-stoning of mucosa	Uncommon	Uncommon	Common
Fistulas	Uncommon	Rare	Common
Anal or perianal disease	Rare	Absent	Common