Does Intraperitoneal Chemotherapy Increase the Incidence of Anastomotic Leakage after Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis

Table 1

Basic characteristics of the included studies.

Study	Type of study	Years of the study	IC method	Patient number		AL number		Risk of bias
				IC	No IC	IC	No IC
Zhang et al., 2017	RCT	2011.01–2016.01	300 mg/m^2 5-FU poured into the abdominal cavity	341	344	4 (1.2%)	4 (1.2%)	High
Yuan et al., 2015	RCT	2007.06–2008.07	Implant 5-Fu (600 mg) into the abdominal cavity	98	104	4 (4.1%)	4 (3.8%)	High
Wang et al., 2019	Retrospective cohort	2016.09–2017.09	Implant Fu (500-1000 mg) into the abdominal cavity or poured lobaplatin (60 mg) into the abdominal cavity	171	306	13 (7.6%)	5 (1.6%)	High
Averbach et al., 1996	Retrospective cohort	1988–1994	Mitomycin C (10 mg/m^2 BSA) and 5-Fu (15 mg/kg body weight) poured into the abdominal cavity	117	18	6 (5%)	1 (6%)	Moderate

RCT: randomized controlled trial; IC: intraperitoneal chemotherapy; Fu: fluorouracil; BSA: body surface area.