The Role of T Follicular Helper Cells and Interleukin-21 in the Pathogenesis of Inflammatory Bowel Disease

Figure 1

The differentiation of Tfh cells. Naive CD4⁺ T cells are primed by MHC/antigen interaction with DCs and differentiate to pre-Tfh cells; then, pre-Tfh cells migrate to the T-B border and interact with cognate B cells; finally, interactions between pre-Tfh cells and B cells lead to the formation of GC Tfh cells.