Usefulness of Measuring Thiopurine Metabolites in Children with Inflammatory Bowel Disease and Autoimmunological Hepatitis, Treated with Azathioprine

Figure 1

Azathioprine metabolism. AZA: azathioprine; HPRT: hypoxanthine phosphoribosyltransferase; IMPDH: inosine monophosphate dehydrogenase; GMPS: guanosine monophosphate synthase; ITPase: inosine triphosphatase; XO: xanthine oxidase; TPMT: thiopurine S-methyltransferase; 6-MP: 6-mercaptopurine; 6-MMP: 6-methylmercaptopurine; 6-MTIMP: 6-methylthioinosine monophosphate; 6-TXMP: 6-thioxanthylic acid; 6-TGNs: 6 thioguanine nucleotides; 6-TIMP: 6-thioinosine monophosphate; 6-TITP: 6-thioinosine triphosphate; 6-TU: 6-thiouric acid.