Research Article
Risk Factors for Worsening of Bone Loss in Patients Newly Diagnosed with Inflammatory Bowel Disease
Table 4
Univariate and multivariate analysis of risk factors for bone loss in patients newly diagnosed with inflammatory bowel disease.
| | IBD | CD | UC | Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | | | OR (95% CI) | | | OR (95% CI) | | | OR (95% CI) |
| Disease type | 0.658 | | | NA | NA | | NA | NA | | Age at diagnosis (year) | 0.023 | 0.037 | 2.320 (1.155–4.854) | 0.056 | 0.23 | 1.003 (0.703–1.432) | 0.036 | 0.043 | 4.896 (1.223–18.607) | Sex | 0.382 | | | 0.689 | | | 0.244 | | | BMI (kg/m2) | <0.001 | 0.005 | 0.373 (0.206–0.692) | 0.004 | 0.022 | 0.573 (0.348–0.862) | <0.001 | 0.002 | 0.445 (0.263–0.765) | Smoking | 0.102 | | | 0.236 | | | 0.754 | | | Alcohol intake | 0.512 | | | 0.059 | 0.836 | 0.974 (0.760–1.249) | 0.343 | | | Symptom duration (months) | 0.879 | | | 0.939 | | | 0.623 | | | Menopause | 0.760 | | | 0.865 | | | 0.136 | | | Hospitalizations | 0.389 | | | 0.454 | | | 0.613 | | | Intestinal surgery history | 0.864 | | | 0.882 | | | 0.471 | | | Body composition | | | | | | | | | | FMI (kg/height m2) | 0.056 | 0.408 | 0.902 (0.653–1.247) | 0.209 | | | 0.142 | | | ASMI (kg/height m2) | 0.127 | | | 0.354 | | | 0.481 | | | Biochemical characteristics | | | | | | | | | | CRP (mg/L) | 0.778 | | | 0.403 | | | 0.914 | | | Albumin (g/L) | 0.403 | | | 0.318 | | | 0.632 | | | Calcium (mmol/L) | 0.133 | 0.673 | | 0.219 | | | 0.345 | | | Phosphorus (mmol/L) | 0.089 | 0.018 | 0.562 (0.274–0.831) | 0.026 | 0.003 | 0.456 (0.241–0.864) | 0.131 | 0.654 | 0.872 (0.585–1.310) |
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Abbreviations: IBD: inflammatory bowel disease; CD: Crohn’s disease; UC: ulcerative colitis; BMI: body mass index; FMI: fat mass index; ASMI: appendicular skeletal muscle index; CRP: C-reactive protein; OR: odds ratio; CI: confidence interval.
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