Characterization of Desmoglein 3 (DSG3) as a Sensitive and Specific Marker for Esophageal Squamous Cell Carcinoma
Table 2
Proportion and intensity of immunoreactive cells in esophageal squamous cell carcinoma.
P40 proportion (average, range)
CK5/6 proportion (average, range)
DSG3 proportion (average, range)
SCC WD components
38% (2-70%, )
81% (30-100%, )
87% (60-100%, )
SCC MD components
71% (10-90%, )
87% (20-100%, )
85% (40-100%, )
SCC PD components
90% (90-95%, )
73% (20-100%, )
63% (30-90%, )
SCC all components
66% (2-95%, )
81% (20-100%, )
80% (30-100%, )
P40 proportion range ()
CK5/6 proportion range ()
DSG3 proportion range ()
<5%
5-25%
26-50%
51-75%
>75%
<5%
5-25%
26-50%
51-75%
>75%
<5%
5-25%
26-50%
51-75%
>75%
SCC WD components
1
5
11
3
0
0
0
4
1
15
0
0
0
2
18
SCC MD components
0
1
5
4
16
0
0
1
2
22
0
0
2
0
24
SCC PD components
0
0
0
0
17
0
0
2
3
12
0
0
8
0
9
P40 intensity (number, percentage)
CK5/6 intensity (number, percentage)
DSG3 intensity (number, percentage)
None
Weak
Strong
None
Weak
Strong
None
Weak
Strong
SCC WD components
0
4/20 (20%)
16/20 (80%)
0
1/20 (5%)
19/20 (95%)
0
0
20/20 (100%)
SCC MD components
0
2/26 (8%)
24/26 (92%)
0
2/25 (8%)
23/25 (92%)
0
1/26 (4%)
25/26 (96%)
SCC PD components
0
0
17/17 (100%)
0
6/17 (35%)
11/17 (65%)
0
6/17 (35%)
11/17 (65%)
Abbreviations: SCC: squamous cell carcinoma; WD: well-differentiated; MD: moderately differentiated; PD: poorly differentiated. , P40 or DSG3 proportions in SCC WD vs. MD vs. PD components, one-way ANOVA. , DSG3 strong intensity in SCC WD vs. MD vs. PD components, test. CK5/6 immunostain is not available in one SCC case with MD component only.
