Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier

Table 1

Potential clinical value of clock genes for management of IBD.

Clinical value	Method
Early prediction of the occurrence of IBD	Analysis of clock gene expression levels in peripheral blood and intestinal mucosa samples [93]
Finding new drug targets for treating IBD	Rev-erbα is expected to be a drug target for the prevention and control of colitis [94]
Assessing the prognosis of colitis-related colorectal cancer	Detection of Bmal1 gene in paracancerous tissue and central tumor tissue [95]