IL-6 Promotes Hepatocellular Carcinoma Invasion by Releasing Exosomal miR-133a-3p

Figure 3

miR-133a-3p in exosomes can inhibit the invasion and metastasis of tumor cells. (a, b) The cluster heat map demonstrates the differentially expressed miRNAs. Rows represent miRNAs while columns represent tissues. S1 and S2 represent the miRNAs of MHCC-97L cells with/without IL-6 treatment, while S3 and S4 represent the exosomal miRNAs of MHCC-97L cells with/without IL-6 treatment, respectively. (c) Overlapping expression miRNAs in different groups is illustrated using a Venn diagram. (d) Real-time PCR showing the relative expression of miR-133a-3p in different HCC cell lines. (e, f) Transwell assay showing the invasive ability of MHCC-97L and HCCLM3 cells upon treatment with miR-133a-3p inhibitor and mimic, respectively. (g) The effect of miR-133a-3p inhibitor and mimic on the proliferation of HCC cells. . Nc: negative control.

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