IL-6 Promotes Hepatocellular Carcinoma Invasion by Releasing Exosomal miR-133a-3p

Figure 4

Bioinformatic analysis reveals the hub genes of IL-6/miR-133a-3p axis. (a) Identification of 3973 differentially expressed genes (DEGs) by comparing the metastatic HCC with nonmetastatic HCC based on the GSE40367 database. The volcano plot demonstrates the fold changes and statistical significance. (b) Venn diagram illustrating the overlapping expression genes between 3973 DEGs and 571 target genes. GO analysis of the 140 overlapping expression genes indicating (c) molecular functions (MF), (d) biological processes (BP), and (e) cellular components (CC). (f) KEGG pathway analysis. (g) PPI network analysis reveals the hub genes. (h–k) Overall survival analysis of the hub genes by Kaplan-Meier plots. The values were calculated using log-rank statistics.

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