Progress on the Mechanism of Visceral Hypersensitivity in Nonerosive Reflux Disease

Figure 1

Endogenous or exogenous stimulation can activate acid-sensitive receptors, affect the function of the cerebral cortex, activate the brain-gut axis, and eventually lead to central hyperexcitability, inflammation, immune response, hyperalgesia, and intestinal microbial disorders through the release of neuropeptides (SP and CGRP) or brain-gut peptides. These factors jointly play an important role in the VH of NERD.