Review Article

Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease

Table 1

Mechanisms of acupuncture intervention in nonalcoholic fatty liver disease.

CategoryResearch objectAcupuncture pointsMechanism of actionReferenceYear

Inhibit inflammationRatPi shu (BL20), Shen shu (BL23), and Ge shu (BL17)Inhibits TNF-α expression[14]2014 Y
RatZu san li (ST36), San yin jiao (SP6), and Feng long (ST40)Inhibits TNF-α expression[15]2018 Y
RatZu san li (ST36), San yin jiao (SP6), and Feng long (ST40)Inhibits IL-6 expression[17]2014 Y
RatFeng long (ST40), Zu san li (ST36)Inhibits TNF-α and IL-6 expression[18]2018 Y
RatZu san li (ST36), San yin jiao (SP6), Feng long (ST40), and Tai chong (LR3)Inhibits IL-18 expression[20]2013Y
RatYin ling quan (SP9), Feng long (ST40), and San yin jiao (SP6)Regulates Sirt1/NF-κB pathway[24]2020Y
Improve lipid metabolism disorderMiceZu san li (ST36), Guan yuan (CV4), and Yong quan (KI1)Reduces lipid synthesis and promotes lipid metabolism[29]2019Y
PersonFeng long (ST40), Zu san li (ST36)Improves hemorheological index[30]2021Y
MiceZu san li (ST36), Guan yuan (CV4), and Yong quan (KI1)Inhibits intestinal lipid absorption and reduces lipid accumulation[31]2020Y
Antagonize oxidative stressRatDouble side tape (GB26)Decreases MDA content and increases t-SOD and GSH-Px activities[33]2019Y
MiceZu san li (ST36), Guan yuan (CV4), and Yong quan (KI1)Inhibits the expression of 8-OHdG and TBARS and increases the expression of GPX1, 2, 3, and GSS[29]2019Y
MiceZu san li (ST36), Guan yuan (CV4), and Yi yu (EX-B3)Decreases MDA content and increases SOD activity, as well as regulates apoptosis expression of Bax and Bcl-2[34]2020Y
Improve endoplasmic reticulum stressRatFeng long (ST40), San yin jiao (SP6)Inhibits the expression of SrebP-1C and downregulates FAS activity[40]2018Y
RatFeng long (ST40), Zu san li (ST36)Inhibits the expression of SrebP-1C[41]2017Y
RatZu san li (ST36), San yin jiao (SP6)Inhibits the expression of SrebP-1C
Inhibits the expression of ERp57 and SREBP-1C
[42]2016Y
RatZu san li (ST36), San yin jiao (SP6)Inhibits the expression of GRP78[43]2016Y
Improve insulin resistanceRatZu san li (ST36), San yin jiao (SP6), Feng long (ST40), and Tai chong (LR3)Decreases the levels of FPG, FINS and HOMA-IR, and FFA concentration[45]2008Y
PersonZhong wan (CV12), Qu chi (LI11), Shui fen (CV9), Guan yuan (CV4), Qi hai (CV6), Feng long (ST40), San yin jiao (SP6), Tai chong (LR3), Xue hai (SP10), Hua rou men (ST24), and Da heng (SP15)Decreases the levels of FPG, FINS, and HOMA-IR[8]2020Y
RatFeng long (ST40), Tai chong (LR3)Increases ADP levels and reduces LP, FFA, and CREP levels[46]2018Y
RatFeng long (ST40), San yin jiao (SP6)Inhibits the IKK/NF-κB pathway and increases irS-1 activity[47]2021Y
RatZu san li (ST36), Feng long (ST40), Zhong wan (CV12), and Guan yuan (CV4)Activates the SIRT1/ATG7 pathway and reduces liver fat deposition[48]2021Y