Melatonin Alleviates Neonatal Necrotizing Enterocolitis by Repressing the Activation of the NLRP3 Inflammasome

Figure 5

MEL attenuated the mRNA levels of NLRP3, TLR4, NF-κB, and caspase-1 of the terminal ileum tissues in NEC mice. (a–d) The effect of MEL on the mRNA levels of NOD-like receptor family pyrin domain containing 3 (NLRP3), Toll-like Receptor 4 (TLR4), NF-kappaB (NF-κB), and caspase-1 of the terminal ileum tissues in NEC mice was estimated by quantitative real-time PCR (qRT-PCR). ^▲▲ vs. control; ^★★ vs. NEC.

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