Effect of Coffee Consumption on Postoperative Ileus after Colorectal Surgery: A Meta-Analysis of Randomized Controlled Trials
Table 1
Characteristics of included studies.
Author
Year
Center
Location
Participants
Surgical information
Intervention
Sample size (I/C)
Sex (M:F I/C)
Age (I/C, year)
Fast-track surgery
Colorectal pathology (M:B I/C)
Type of surgery
Operation time (range) (I/C, min)
Coffee
Volume (ml)
Drink time (min)
Frequency
Control
Muller
2012
Multicenter
Germany
40/39
25 : 15/19 : 20
65/59
Applied
23 : 17/22 : 17
Open and laparoscopy
Caffeinated
100
10
TDS
Water
Dulskas
2015
Single-center
Lithuania
30/(DC:30/W:30)
16 : 14/16 : 14/16 : 14
67.3/62.4/66.3
Applied
30 : 0/30 : 0/30 : 0
Laparoscopy
Caffeinated DC
100
10
TDS
Water
Piric
2015
Single-center
Bosnia and Herzegovina
28/30
17 : 11/17 : 13
63.57/62.67
NM
25 : 3/28 : 2
Open
Caffeinated
100
10
TDS
Tea
Hasler-Gehrer
2019
Single-center
Switzerland
56/59
31 : 25/28 : 31
63/69
NM
23 : 33/29 : 30
Laparoscopy
160 (136–185) /150 (130–180)
Caffeinated
150
NM
TDS
Tea
Hayashi
2019
Single-center
Japan
23/23
5 : 18/7 : 16
74.0/80.2
Applied
0 : 23/0 : 23
Laparoscopy
181.6 (120-266)/177.0 (107-333)
Caffeinated
100
10
TDS
Water
Parnasa
2021
Single-center
Israel
30/28
15 : 15/14 : 14
56.90/55.36
NM
NM
Laparoscopy
NM
Caffeine citrate
50
NM
TDS
Apple-flavored water
100 mg of caffeine citrate was diluted in 50 ml of apple-flavored water. I: coffee group; C: control group; sex (M: male; F: female); colorectal pathology (M: malignancy; B: benign); DC: decaffeinated coffee; W: water; NM: not mentioned; TDS: three times per day.
