Efficacy and Safety of Endoscopic Submucosal Dissection for Dysplasia in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis

Table 2

Clinical and technical characteristics of the included studies.

Author

Mean size (mm)

Location (, R/L)

Morphology (, P/NP)

Surface ulcer ()

Border (, clear/unclear)

Surrounding mucosa (, R/A)

Submucosal fibrosis (, Y/N)

Mean procedure type (min)

En bloc resection ()

Complete resection ()

Curative resection ()

Histopathology ()

Iacopini et al. [14]

36.25

2/8

0/10

0

10/0

10/0

9/1

75.25

8

8

7

SSA 1, LGD 4, HGD 3, adenocarcinoma 2

Suzuki et al. [15]

33

0/32

2/30

NA

32/0

29/3

31/1

87

29

23

NA

LGD 19, HGD 7, adenocarcinoma 4, regenerative atypia 2

Kinoshita et al. [16]

21.6

8/17

5/20

NA

25/0

25/0

25/0

71.7

25

19

14

LGD 7, HGD 4, adenocarcinoma 14

Yang et al. [17]

26.5

1/14

1/14

0

15/0

15/0

10/5

73.5

14

12

NA

SSA/P 1, IND 1, LGD 8, HGD 3, adenocarcinoma 2

Matsumoto et al. [18]

18.25

0/12

2/10

NA

12/0

10/2

12/0

52.5

10

8

8

LGD 9, HGD 3

Nishio et al. [19]

19

12/27

4/35

0

39/0

39/0

NA

67

38

38

38

LGD 17, HGD 13, serrated polyps 9

Manta R et al. [20]

34

NA

NA

0

NA

53/0

29/24

NA

53

51

51

LGD 37, HGD 14, IND 1 hyperplastic polyp 1

Matsui et al. [21]

25.1

2/15

1/16

NA

17/0

NA

1/16

155

17

12

12

Adenoma 2, LGD 4, HGD 4, adenocarcinoma 7

NA: not available; R/L: right colon/left colon; P/NP: polypoid/nonpolypoid; R/A: remission/active; Y/N: yes/no; LGD: low-grade dysplasia; HGD: high-grade dysplasia; IND: indefinite dysplasia; SSA/P: sessile serrated adenoma/polyp. Right colon including cecum, ascending colon, and transverse colon. Left colon including descending colon, sigmoid colon, and rectum. Polypoid including pedunculated and sessile lesions. Nonpolypoid including superficial elevated, flat and depressed lesions, and laterally spreading tumor.