EMP1 as a Potential Biomarker in Liver Fibrosis: A Bioinformatics Analysis

Figure 1

Identification of DEGs in CCl₄-treated mouse liver samples. DEGs were obtained by comparing untreated and CCl4-induced fibrotic mouse liver tissues from three GEO datasets: GSE14182, GSE55747, and GSE80601. (a)–(c)) Volcano plot of the distribution of all DEGs between untreated control and CCl₄-treated liver samples from GSE14182, GSE55747, and GSE80601, respectively, with a threshold of |log₂(foldchange)| >1 and adjusted (the brick red, upregulated DEGs; grass green: downregulated DEGs; grey: unchanged). (d)–(f) The heatmap plot of DEGs across the samples (CCl₄-treated vs Control) from GSE14182, GSE55747, and GSE80601, respectively. Colors above the heatmap indicate sample groups. Each row of the heatmap represents the normalized expression values of one differentially expressed gene across all samples (grass green, low expression; brick red, high expression). (g) and (h) Venn diagram of DEGs from 3 different microarray dataset. CCl₄, carbon tetrachloride; DEG, differential expressed genes; GEO, Gene Expression Omnibus.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)