EMP1 as a Potential Biomarker in Liver Fibrosis: A Bioinformatics Analysis

Figure 3

EMP1 is a marker gene for fibrotic liver in both animal and human samples. Emp1 upregulation in CCl₄-treated mouse liver samples compared with normal tissues in GSE80601 (a), GSE27640 (b), GSE73499 (c), and GSE139994 (d). Emp1 expression elevation in mice BDL model compared with sham group (e). Positive association of EMP1 expression with alcoholic hepatitis (GSE28619) (f) and alcoholic cirrhosis (GSE103580) samples (g). Increased expression of EMP1 in liver samples with advanced stage of fibrosis (stage 3–4) compared with mild (stage 0–1) (h). In the rat model, Emp1 expression is greatest in the NASH group compared to the NAFL, NAFLD + T2DM, and healthy control groups. BDL, bile duct ligation (i); CCl₄, carbon tetrachloride; EMP1, epithelial membrane protein 1; NAFL, nonalcoholic fatty liver; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; T2DM, type 2 diabetes; * and ***.

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