EMP1 as a Potential Biomarker in Liver Fibrosis: A Bioinformatics Analysis

Figure 4

EMP1 is expressed in activated fibrotic hepatic stellate. The cell type atlas given by Protein Atlas (https://www.proteinatlas.org/) validated the expression of EMP1 in liver tissues. (a) Feature plot of EMP1 overlaid with the UMAP projection of liver samples. (b) Bar plot showing the TPM expression of EMP1 across different cell type clusters including hepatocytes, Ito cells, T cells, Kupfer cells, B cells, and others. (c) Heatmap plot of normalized EMP1 expressions along with other marker genes across the different cell types in liver tissues. Significant positive association of EMP1 expression with fibrotic HSCs (GSE120281) (d) and activated fibroblast introduced by either CCl₄ treatment or Western diet-fed NASH model (GSE134512) samples (e). CCl₄, carbon tetrachloride; EMP1, epithelial membrane protein 1; NASH, nonalcoholic steatohepatitis; TPM, transcripts per million; UMAP, Uniform Manifold Approximation and Projection. and ***.

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